For 40 years, we’ve helped scientists harness the full potential of biology with next-generation technology. Here we share the latest in automated, end-to-end solutions that span research disciplines to advance scientific discovery and improve the quality of human life worldwide.
NEWS ARTICLE
Overcoming Challenges in STEM to Build a Successful Career
In recognition of Women’s History Month, Labcompare recently spoke with Corena Grant and Serena Cervantes, two female field application specialists at Molecular Devices. In this eQ&A, Grant and Cervantes share the challenges and opportunities as women in STEM and a largely male-dominated field.
Are you ready to work with organoids? Our senior manager of assay development Oksana Sirenko, Ph.D., and industry peers share a few key prep tips to optimize organoid imaging in this Biocompare piece.
Discover how to:
Choose culture-ware designed to produce uniform structures that suspend in place
Optimize staining protocols for 3D cultures, which may require increased fixation and permeabilization times, and concentrations of reagents to compensate for the thicker structures
Enhance sample transparency by using clearing agents
To learn more, read on for all of the imaging insights.
The fundamentals of cultured meat production: Understand the science behind creating meat from cell cultures and the role of biotechnology in transforming food production.
Technological advancements from Molecular Devices: Discover how cutting-edge tools and technologies are critical for research and development in cultured meat production.
Practical applications and challenges: Learn about the implementation of these technologies in real-world scenarios, addressing both the potential and the hurdles of cultured meat production.
Impacts on global food sustainability: Explore how cultured meats can contribute to reducing environmental impact and meeting global food demands sustainably.
Finding efficient anti-cancer drugs and drug combinations is critical for therapy success.
To expedite and standardize the spheroid assay, we developed 3D cell culture automation methods using the CellXpress.ai™ Automated Cell Culture System to provide automated plating, passaging, media exchange, and organoid monitoring in response to compound treatment, and endpoint assays.
Read the app note where we describe an end-to-end cell culture workflow where we automated the culture and imaging of colorectal cancer 3D spheroids formed from HCT116 cell lines in U-shape low attachment plates.
Attrition in the therapeutic pipeline can often be attributed to the lack of translational efficacy from the pre-clinical phase to the clinic.
To alleviate the bottlenecks that come with labor-intensive manual protocols, we developed the CellXpress.ai™ Automated Cell Culture System to automate the entire organoid culture process for prolonged complex workflows. The CellXpress.ai system offers AI-driven, end-to-end cell culture management – from liquid handling to endpoint assay execution to complex image analysis.
In this app note, we present results from an automated intestinal workflow which can be used as the basis for other commonly used 3D organoid protocols in matrix domes.
About five million people in the United States alone live with traumatic brain injuries (TBIs). These injuries can quadruple the risk of developing Alzheimer’s disease, and other dementia types, and increase the likelihood of developing neurodegenerative diseases such as amyotrophic lateral sclerosis. Rodent models of TBI have clarified some aspects of these injuries; however, most treatment approaches have had limited success because some of the details of the underlying mechanisms are still unclear.
In this new GEN webinar, Justin Ichida, PhD, an expert in stem cell biology and regenerative medicine at the Keck School of Medicine at the University of Southern California discusses using organoids to clear up the causes of neuronal damage following TBIs and ways of mitigating injury risks. During the webinar, he’ll present results from a study that used lab-grown human brain organoid models to parse the genetic mechanisms involved in TBIs and explore their connection to neurodegenerative disorders. He’ll also discuss possible methods of treating brain injuries that were identified by the study.
A live Q&A session will follow the presentation, giving attendees a chance to ask questions.
The FLIPR Penta, tailored especially for kinetic screening for toxicology and lead compound identification, is a customizable, all-in-one, high-throughput cellular screening system.
Our latest virtual demo showcases FLIPR Penta's:
Newly enhanced HS EMCCD camera option, which allows up to 100 measurements per second and provides detailed information about cardiomyocyte and neuronal oscillation
LED Excitation Banks, which can accommodate various assay types including calcium flux, membrane potential, and potassium
User-interchangeable pipettor heads, which can accommodate manual and automated assays in 96-, 384-, and 1536- well throughputs
Newly updated ScreenWorks® Peak Pro 2 Software, which can calculate calcium oscillation peak data and quickly flag abnormalities, including defibrillation, deploarization, and irregular beating
Check out our FLIPR Penta interactive demo to see how this system makes the transition from assay development to lead optimization a seamless process.
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